Each 20 mg and 1 g vial of lyophilized powder contains methotrexate sodium equivalent to 20 mg and 1 g methotrexate respectively. Methotrexate mtx has been a valuable treatment for rheumatoid arthritis ra for more than 30 years, and it remains the anchor drug for ra therapy. This type of injection is much easier to do than the one into the muscle and is less painful as the needle is much thinner. Otrexup, rasuvo, and reditrex are only for once a week use and is not to be used daily. At birth, the blood concentration of vitamin b12 imneonates is 3 to 5 times that of the mother. Methotrexate injection side effects, medical uses, and. Treat certain adults with severe, active rheumatoid arthritis, and children with active polyarticular juvenile idiopathic arthritis pjia, after treatment with other medicines including nonsteroidal antiinflammatory drugs nsaids. Methotrexate injection, usp is sterile and nonpyrogenic and may be given by the intramuscular, intravenous, or intraarterial route see dosage and administration. Neoral soft gelatin capsules cyclosporine capsules, usp. Each 25 mgml, 2 ml vial contains methotrexate sodium equivalent to 50 mg methotrexate, 0. Methotrexate is also indicated in the treatment of meningeal leukemia. The inactive ingredient is sodium chloride 140 mgvial for the 350 mg vial. Avoid injecting into areas with scars or stretch marks.
The preserved formulation contains benzyl alcohol and must not be used for intrathecal or high dose therapy. If your child has juvenile idiopathic arthritis jia, he or she may already be using injectable mtx. Methotrexate injection, usp 250 mg per 10 ml 25 mg per ml contains preservative. Dailymed methotrexate methotrexate sodium injection. Otrexup is a once weekly medication that 98% of ra patients studied agreed was easy to use. The lower abdomen, thighs and upper arms are easiest for injection. Shingrix is not indicated for prevention of primary varicella infection chickenpox. Learn about side effects, warnings, dosage, and more. Treatment of candidemia, acute disseminated candidiasis. Do not inject into skin that is tender, damaged, or has bruises or scars.
Treat certain adults with severe, active rheumatoid arthritis, and children with active polyarticular juvenile idiopathic arthritis. Each tablet contains methotrexate sodium in an amount equivalent to the labeled amount of methotrexate, usp, and contains the following inactive ingredients. Serious infections leading to hospitalization or death including. When a dose of 100 mgkg of body weight is given initially and followed by 50 mgkg every 6 hours, blood levels of free sulfadiazine are about 7 mg100ml. Although mtx is generally safe, intolerability may be an important cause of treatment discontinuation and often includes gastrointestinal gi adverse events aes 46. Accidental ingestion safe handling practices include preparing, transporting, administering, andor disposing of material wastes. Each vial contains either mitomycin 5 mg and mannitol 10 mg, or mitomycin 20 mg and mannitol 40 mg, or mitomycin 40 mg and mannitol 80 mg. Methotrexate injection usp without preservative may be given by the intramuscular, intravenous as a bolus, intraarterial, intrathecal or intraventricular via ommaya reservoir into the cns routes. You should not repeat injections into the same spot. Other forms of methotrexate include oral tablets and solutions for injection. Methotrexate injection usp formulations which contain benzyl alcohol as preservative are contraindicated in neonates and for intrathecal, intraventricular, or highdose therapy see contraindications. Self injection of methotrexate education package information for patients carers.
Exposure to premixed, injectable methotrexate can occur by. The clinical formulation is supplied in a sterile form for intravenous use only. Risk of serious infections see full prescribing information for complete boxed warning. If you have any further questions, ask your doctor or pharmacist. Methotrexate injection, usp is sterile and nonpyrogenic and may be given. Methotrexate injection fda prescribing information, side. Leucovorin calcium for injection leucovorin calcium for injection is indicated for intravenous or intramuscular administration and is supplied as a sterile lyophilized powder. Trexall fda prescribing information, side effects and uses. Cyclophosphamide for injection, usp is a sterile white powder containing cyclophosphamide monohydrate. Leucovorin may limit methotrexate action on normal cells by competing with methotrexate for the same transport processes into the cell. Once the needle is in place, release your pinch on the.
Methotrexate tablets, usp contain an amount of methotrexate sodium equivalent. Information on methotrexate methotrexate is a slow acting drug, which reduces disease activity. Vitamin b12 is distributed into the liver, bone marrow, and other tissues, including the placenta. It is freely soluble in water, soluble in methanol, and slightly soluble in ethanol. The catalog displays all strengths and sizes along with the description, imprint code, ndc and photo for each product. Highlights of prescribing information these highlights do not include all the information needed to use humira safely and effectively. Sulfadiazine diffuses into the cerebrospinal fluid.
Women must avoid becoming pregnant while using this medication. Methotrexate injection, usp, isotonic liquid, preservative free, for single use only, is available in 10 mgml, 2 ml 20 mg vials and 25 mgml, 20 ml 500 mg, 40 ml 1 g and 100 ml 2. Otrexup contains methotrexate in a preservativefree sterile solution for a single subcutaneous injection. Otrexup, rasuvo, and reditrex are folate analog metabolic inhibitors indicated for. Pregnant women who have psoriasis or rheumatoid arthritis must not use methotrexate. Mitomycin for injection is a sterile dry mixture of mitomycin and mannitol, which, when reconstituted with sterile water for injection, provides a solution for intravenous administration. The product catalog provides you with a full listing of tevas brand and generic product lines. Information for the user methotrexate 25 mgml injection read all of this leaflet carefully before you start using this medicine. Each ml contains methotrexate sodium equivalent to 25 mg. Methotrexate formerly amethopterin is an antimetabolite used in the treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis. If you have any further questions, ask your doctor or pharmacist or. Rasuvo methotrexate injection is a singledose autoinjector containing a prescription medicine, methotrexate.
Aminophylline injection, usp is a sterile, nonpyrogenic solution of aminophylline in water for injection. By the mid 1990s, studies indicated that methotrexate is also well absorbed when injected into the fatty layer just under the skin subcutaneous. Treat certain adults with severe, active rheumatoid arthritis, and children with active polyarticular juvenile idiopathic arthritis pjia, after treatment with other medicines including nonsteroidal antiinflammatory nsaids have. If all or part of antares is sold or merged into another entity, the information we have about you may be transferred to a third party as part of that transaction. Methotrexate rasuvo, otrexup is a selfinjectable solution used to treat psoriasis and rheumatoid arthritis. Make sure the needle does not come into contact with anything on the way to the skin 4. Methotrexate sodium for injection, lyophilized, preservative free, for single use only, is available in 20 mg and 1 gram vials. Trexall methotrexate tablets usp, for oral administration, is available in 5 mg, 7. In the case of subcutaneous methotrexate autoinjector pens, many people have noted they are relatively painfree to use. Do not inject into areas where the skin is tender, bruised, red, or hard. Methotrexate methotrexate pfizer medical information. Cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards.
If you want to use the same injection site, make sure it is not the same spot on the injection site area you used for a previous injection. Aminophylline dihydrate is approximately 79% of anhydrous theophylline by weight. Methotrexate tablets, usp for oral administration are available in a packaging system designated as the rheumatrex methotrexate tablets, usp dose pack for therapy with a weekly dosing schedule of 5 mg, 7. Actemra subcutaneous formulation is not intended for. Highlights of prescribing information these highlights do. The vial can be used for more than one dose because it contains a preservative called benzyl alcohol to keep it clean sterile between uses. Methotrexate is used alone or in combination with other anticancer agents in the treatment of breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides cutaneous t cell lymphoma, and lung cancer. Finally, you and your doctor may prefer an autoinjector pen over a syringe and vial because it can deliver more accurate doses of methotrexate. It can be given by mouth or injection and is usually given once a week. For patients with inflammatory arthritis, methotrexate is supplied as 50 mg in a 2 ml vial 25 mg per 1 ml. It prevents the growth of the white blood cells that cause inflammation.
Here are some important features of the vials of methotrexate. Vials of vinblastine sulfate for injection usp contain 10 mg. Methotrexate has caused birth defects and death in unborn babies. Leucovorin rescues bone marrow and gastrointestinal cells from methotrexate but has no apparent effect on preexisting methotrexate nephrotoxicity. Treatment of candidemia, acute disseminated candidiasis, candida peritonitis and abscesses in adult and pediatric patients 4 months of age and older see clinical studies 14. It is important to take methotrexate on the same day each week.
Methotrexate sodium for injection products are sterile and nonpyrogenic and may be given by the intramuscular, intravenous, intraarterial or intrathecal route. The best areas are shown in the image light blue areas. It may take up to 3 months, during which time the dose may need to be adjusted, to have its full effect. Also, autoinjector pens may be associated with reduced pain on injection. Psoriasis patients previously treated with puva and to a lesser extent, methotrexate or other immunosuppressive agents, uvb, coal tar, or radiation therapy, are at an increased risk of developing. Methotrexate injection, usp isotonic liquid, contains preservative is available in 25 mgml, 2 ml 50 mg vials. Methotrexate has caused birth defects and death in. Cimzia is provided in a package that contains everything required to reconstitute and inject the drug see how suppliedstorage and handling 16. Guide for adult patients self administering methotrexate.